The all-rounder will replace Owais Shah, who was hastily brought into the side following Mascarenhas' late injury for his first appearance of the series.
Flintoff, meanwhile, could skipper England if illness prevents Paul Collingwood from leading the side.
Only five months after being stripped of the vice-captaincy for his role in the drinking antics during the World Cup in St Lucia, Flintoff is ready to lead out the side again if Collingwood fails to recover from the stomach cramps which prevented him attending practice at Old Trafford yesterday.
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