While both teams have a rich history, they haven't faced off too frequently. That said, there have been 10 meetings between the two teams since 2005.
Results show how evenly matched the two teams have been during these meets. Saints and Preston have won three games each and four have ended in draws.
Their upcoming match takes place this evening when Southampton will be hoping to tip the scales in their favour at St Mary's Stadium.
These pictures were taken during the matches between 2005 and now.
Preston v Southampton - October 1, 2005
Southampton v Preston - February 15, 2006
Southampton v Preston - August 26, 2006
Preston v Southampton - March 5, 2007
Preston v Southampton - October 2, 2007
Southampton v Preston - December 22, 2007
Preston v Southampton - November 1, 2008
Southampton v Preston - February 21, 2009
Southampton v Preston - September 21, 2011
Preston v Southampton - October 25, 2023
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