More than 80 firefighters are tackling a blaze in Bitterne Road West this morning.
Hampshire Fire and Rescue Service were called to a commercial garage just after 5am on Sunday.
LIVE UPDATES: Firefighters tackle huge blaze in Southampton
Crews have been tackling the fire since, and a massive plume of smoke has been seen over the city.
Firefighters have issued a warning to residents in the area to keep their windows and doors closed.
A spokesperson for Hampshire Fire and Rescue Service said: "Crews are currently attending a fire on Bitterne Road West, Southampton. The initial call was received at 05:05. The fire has impacted a commercial garage. Presently, 11 fire engines, 2 aerial ladder platforms, and other specialist vehicles are on site.
"Residents in the vicinity are advised to keep windows and doors closed due to heavy smoke.
"The public is advised to avoid the area to facilitate the movement of emergency vehicles."
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