Jet-lagged manager Nick Holmes returned from America - but his side for his hangover as Salisbury slithered out of the FA Trophy in a bad-tempered 1-0 home defeat by DML Eastern Division Clevedon Town.
The Whites made life difficult for themselves as they played for 78 minutes with ten men after striker Leigh Phillips was shown a straight red card following a nasty challenge on ex-Arsenal midfielder David Hillier.
Phillips's red came two minutes after referee Mackrell had waved away strong penalty appeals when Shane Andrews clearly pushed the Salisbury front-man in the penalty area.
It was Salisbury's third red card in two games following the dismissals of Adam Wallace and Josh Thomas in the midweek FA Cup replay win at Westbury.
Mackrell further incensed the home crowd, showing only yellow to Clevedon's Danny Bryant for a tackle on Adam Wallace that ranked alongside that of Phillips.
The referee was unable to continue after the break and, after a long delay, it was Clevedon who began to make their extra man tell.
On 68 minutes a simple move split the Whites' defence, allowing Hillier to net the winner from Fidel Richards's through ball.
Salisbury assistant manager Tom Killick conceded: "We are a little bit short on confidence at the moment and, when you're down to ten men so early on that doesn't help.
"We didn't create anything and didn't have any fluencey."
Newport IoW's player/assistant manager Taffy Richardson heaped blame on himself for the Islanders' subdued 3-1 exit at Wivenhoe Town.
Barring a good spell at the start of the second half when Jamie O'Rourke cancelled out Ross Taylor's 37th-minute opener for the Ryman hosts, Newport were a shadow of the side that had turfed Tiverton out of the FA Cup seven days earlier.
Darren Bethell lobbed 'keeper Simon Arthur to restore Wivenhoe's lead and Arthur's foul on Bethell saw Nick Haydon make the game safe with a penalty two minutes from time.
Richardson confessed: "Our lads are honest enough but they look to me for guidance because I'm the oldest and I was very poor.
"You've got to be organised and, if I'm not on the ball, then the others are not on the ball either and our attitude was not what it should have been."
Former Saints Academy striker Shea Saunders rifled Fleet into a 22nd-minute lead at Arlesey Town but they were undone 3-1 through second-half replies from Nathan Buckland, Leon Gutzmore and Craig Mickail-Smith.
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