The top versus bottom clash produced a narrow 3-2 win for champions-elect Nursling, who are now homing in on the big prize.
Two wins from their last four matches will clinch the title.
Fair Oak are now locked in a do-or-die battle with North Baddesley for the drop along with already relegated OTs.
Darren Sheales and an own goal gave Nursling a two-goal start. Fair Oak pulled one back but Andy Kemp added a third to make sure.
North Baddesley's recent good form came a cropper as AFC Target assured their own survival with an impressive 6-0 victory with Wale Olufunwa a hat-trick hero. Gareth Smith, Pete Hurst and Darren Walker added singles.
Botley and Mottisfont have not given up on the title yet and are both looking to take the step up to the Hampshire League via a top three finish.
Motts defeated Durley 3-0 but did not open the scoring until Al Bundy lobbed the 'keeper in the 72nd minute, Matt Street then added two further goals, the final one straight from a corner.
Botley had two Jim Quirk goals to thank for their 2-0 win against Eastleigh Comrades who are losing ground.
Shane Bedwell and a Jason Bridges penalty were the difference as Brendon overcame Sporting BTC 2-0 but both will have to settle for mid-table finishes.
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