GRAHAM Potter confirmed three of his Brighton players who started Wednesday night's draw at West Ham would be unavailable to face Saints due to injury.
They include former Saint Adam Lallana.
The midfielder came through the youth ranks at Saints before playing 265 times for the club, scoring 60 goals, as well as spending a spell as captain, before leaving to join Liverpool for a fee of £25million in 2014.
But the 33-year-old will not return to the St Mary's pitch with the Seagulls for Saturday's Premier League contest (3pm).
Lallana, as well as Adam Webster and Jeremy Sarmiento, were all forced off against the Hammers as Brighton battled back to earn a 1-1 draw thanks to Neal Maupay's stunning late equaliser.
Boss Potter said: "He and the two Adams (Webster and Lallana) both suffered and they and Jeremy will certainly not be involved against Southampton.
"They won't be available for the weekend.
"Adam was a slight calf, Lallana his thigh, Jeremy his hamstring.
"It was a bit of muscle bingo there, which is disappointing for us, but we've got a group and we've got a squad to adjust and adapt.
"Clearly it's not the best to lose players."
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