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- ⚽ In a break from Premier League action, Saints host League Two's Grimsby Town.
- ⚽ Ruben Selles leads his first ever cup game as a permanent boss as he looks to lead his side into the quarter-finals of the FA Cup.
- ⚽ Grimsby have reached the fifth round for the first time since the 1995-96 season.
- ⚽ Kick-off from St Mary's Stadium is set for 7:15 PM.
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