Wayne Thomas will suffer the heartbreak of missing Saints' trip to Wembley in the Johnstone's Paint Trophy final after tearing his calf in training.
The defender, who has been a regular in the Trophy team due to cup ties, sustained the injury in training on Friday.
It is a devastating blow for Thomas who missed all of last season through injury.
There is better news of Radhi Jaidi who sat out the MK Dons game with a hamstring strain but is expected to recover in time for Wembley.
Saints boss Alan Pardew told the Daily Echo: "Thomas is definitely out of the final, Radhi was just feeling a little hamstring and I couldn't risk him. We think he might be alright for Tuesday.
"Thomas pulled his calf, we think he's torn it, on Friday."He's played very well and has been getting better as the season has progressed.
"He's been out for a long, long time and I feel sorry for him because he was probably as near as back to his best as he's been so it's a bit of a blow."
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